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5 Facts you should know about
Autoimmune autonomic ganglionopathy (AAG)
1
AAG is an acquired immune-mediated disorder that leads to systemic autonomic failure
2
Symptoms may include severe orthostatic hypotension, fainting, constipation, fixed and dilated pupils, urinary retention, and dry mouth and eyes
3
In idiopathic AAG, the body's own immune system targets a receptor in the autonomic ganglia, which is part of a peripheral nerve fiber
4
If the AAG is paraneoplastic, there is a form of cancer, and the immune system has produced paraneoplastic antibodies in response to the cancer
5
Approximately one-third of people with AAG get better without treatment, but the recovery is often incomplete
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